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Target intelligence / Profile preview
Polyadenylate-binding nuclear protein 1 (PABPN1)
- Target
- PABPN1
- Molecular classification
- RNA-binding protein, Transcription factor
01
Overview
PABPN1 is an abundant nuclear protein that binds to the poly(A) tails of nascent mRNA molecules, playing a crucial role in polyadenylation, mRNA stability, and export. It is also involved in alternative polyadenylation and the regulation of long noncoding RNAs. Expansion mutations in the polyalanine tract of PABPN1 cause oculopharyngeal muscular dystrophy (OPMD).
- Other names
- OPMDPAB2PABIIPABP-2PABP2
02
Mechanism of action
Not applicable, this is not a drug.
03
Biological functions
mRNA processingPolyadenylationRegulation of gene expressionRNA stabilityRNA exportRNA decay
04
Disease associations
Oculopharyngeal muscular dystrophyCancer
05
Safety considerations
Muscle-specific pathology of OPMD despite ubiquitous expression requires further investigation.
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