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Polyamine Biosynthesis

Molecular classification: Metabolic Pathway

Overview

Polyamine biosynthesis refers to the cellular pathways responsible for producing polyamines—small, positively charged organic molecules such as putrescine, spermidine, and spermine. These molecules are essential for cell growth, proliferation, gene regulation, and stability of nucleic acids across all domains of life. Dysregulation of polyamine metabolism is linked to aging, cancer progression, neurodegeneration, and inflammation.

Mechanism of action

Inhibition of ornithine decarboxylase (ODC)

Biological functions

Cell growthCell divisionDNA stabilizationRNA stabilizationGene regulationPlant morphogenesisStress response

Disease associations

CancerAgingNeurodegenerative diseaseInflammation

Interacting drugs

DL-alpha-difluoromethylornithine (DFMO)

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