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Target intelligence / Profile preview
Polyamine deacetylase HDAC10 (HDAC10)
- Target
- HDAC10
- Molecular classification
- Enzyme, Histone modification, Histone Deacetylase, Class IIb Histone Deacetylase
01
Overview
HDAC10 is a class IIb histone deacetylase primarily functioning as a polyamine deacetylase, selectively deacetylating long-chain polyamines such as N8-acetylspermidine. It plays roles in epigenetic regulation, autophagy, and cell cycle control. HDAC10 is a potential therapeutic target in cancer due to its involvement in tumor growth regulation and autophagy modulation, with both oncogenic and tumor-suppressive roles depending on cellular context.
- Other names
- Histone deacetylase 10
02
Mechanism of action
Inhibition of HDAC10 enzymatic activity, leading to increased acetylation of target proteins (polyamines and potentially histones) and modulation of downstream signaling pathways.
03
Biological functions
Epigenetic regulationPolyamide metabolismAutophagyCell cycle controlTranscriptional repression
04
Disease associations
Cancer
05
Safety considerations
Potential for off-target effects due to structural similarities with other HDACsContext-dependent effects on tumor growth and metastasis
06
Biomarkers
HDAC10 expression levels in tumor tissue
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