Polyamine metabolic pathway enzyme

Polyamine metabolic pathway enzymes" is an umbrella designation for the set of enzymes catalyzing biosynthesis, interconversion, transport, and catabolism of polyamines such as putrescine, spermidine, and spermine. Major enzymes include ornithine decarboxylase (ODC), S-adenosylmethionine decarboxylase (AdoMetDC), spermidine synthase, spermine synthase, spermine oxidase, and various amine oxidases[1][6]. These enzymes are responsible for maintaining cellular polyamine homeostasis, with pivotal roles in cell proliferation, nucleic acid stabilization, transcriptional regulation, and cellular response to stress[1][2][3]. Because polyamines are essential for cell cycle progression and are upregulated in rapidly dividing cells, the pathway is a therapeutic target, especially in oncology (e.g., through ODC inhibition with DFMO)[2][4]. However, the provided name is problematic as a "target" entry, since it does not denote a single gene product, protein, or drug target but rather a class or network of enzymes involved in polyamine metabolism. Specific targets should be referenced individually (e.g., ornithine decarboxylase)[2][4][6].

Other names

Polyamine pathway enzymesPolyamine biosynthetic enzymesPolyamine catabolic enzymes

Inhibition of enzymatic activity to lower intracellular polyamine levels (e.g., ODC inhibition by DFMO); Disruption of polyamine-mediated cell cycle progression; Blockade of polyamine uptake/transport pathways