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Polyamine Metabolism
- Molecular classification
- Metabolic Pathway
01
Overview
Polyamine metabolism refers to the cellular processes that govern the synthesis, catabolism, and transport of polyamines—small organic molecules containing two or more amino groups. The most common naturally occurring polyamines in mammals are putrescine, spermidine, and spermine. These molecules are essential for cell growth, division, gene regulation, DNA stability, protein synthesis, and a variety of other fundamental biological functions. Dysregulation is implicated in several diseases, particularly cancer, making it a therapeutic target.
02
Mechanism of action
Pharmacologic inhibition of biosynthetic enzymes; Genetic manipulation to reduce polyamine levels
03
Biological functions
Cell proliferationCell differentiationGene expression regulationDNA stabilizationProtein synthesisModulation of ion channelsHomology-directed DNA repairImmune response
04
Disease associations
Cancer progressionCancer metastasisImmune evasionAging
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