Target intelligence / Profile preview

Polyamine Oxidase (PAO)

Target: PAO
Molecular classification: Enzyme, Flavin Adenine Dinucleotide (FAD)-dependent oxidase

Overview

Polyamine oxidase (PAO) is a flavin adenine dinucleotide (FAD)-dependent enzyme that catalyzes the oxidation of carbon-nitrogen bonds in secondary amino groups of polyamines. It plays a crucial role in polyamine catabolism and interconversion, maintaining cellular polyamine homeostasis. The enzyme-generated hydrogen peroxide acts as a signaling molecule involved in various biological processes. Targeting PAO is of therapeutic interest, especially in cancer, due to the elevated polyamine uptake and metabolism in cancer cells.

Other names: Spermine oxidaseSpermidine oxidaseN1-acetylspermine oxidaseN1-acetylspermidine oxidase

Mechanism of action

Oxidation of carbon-nitrogen bonds in secondary amino groups of polyamines, using molecular oxygen as an electron acceptor.

Biological functions

Polyamine catabolismPolyamine interconversionRegulation of polyamine homeostasisProduction of hydrogen peroxide (H2O2) as a signaling molecule

Disease associations

CancerNeurodegenerative diseaseStress responses (abiotic/biotic)Cell differentiationSenescenceProgrammed cell death

Safety considerations

Long-term inhibition alters metabolism but does not necessarily provoke behavioral changes in animals.Hydrogen peroxide (H2O2) production may have cytotoxic effects in certain contexts.

Interacting drugs

Selective PAO inhibitors

2 more in the full profile.

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