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Target intelligence / Profile preview
Polyamine-transporting ATPase 13A3 (ATP13A3)
- Target
- ATP13A3
- Molecular classification
- Transporter, P-type ATPase
01
Overview
ATP13A3 is a P-type ATPase involved in transporting various cations, including polyamines like putrescine, spermidine, and spermine. It plays a critical role in maintaining ion balance and cellular clearance mechanisms, particularly in pulmonary vascular cells, where its disruption is linked to PAH. Additionally, ATP13A3 is implicated in the growth of certain cancers, such as pancreatic cancer and neuroblastoma, by facilitating polyamine uptake, which supports tumor growth. As such, it is a potential therapeutic target in these diseases.
- Other names
- AFURS1ATPase family homolog up-regulated in senescence cells 1Putrescine transporting ATPase
02
Mechanism of action
Polyamine transport inhibition
03
Biological functions
Ion transportcellular clearancepolyamine transport
04
Disease associations
Pulmonary arterial hypertension (PAH)pancreatic cancerneuroblastoma
05
Safety considerations
Potential for influencing cellular processes involved in vascular remodelingimplications for cancer and PAH
06
Interacting drugs
AMXT 1501
07
Biomarkers
Expression levels of ATP13A3 for disease prognosis (e.g., neuroblastoma survival)
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