Polycomb group RING finger protein 1 (PCGF1)

Polycomb group RING finger protein 1 (PCGF1) is a key component of variant Polycomb Repressor Complex 1 (PRC1), a multiprotein assembly that establishes and maintains transcriptionally repressive chromatin states crucial for developmental gene regulation[1][2][3][4]. PCGF1 acts as a transcriptional repressor, helping to recruit PRC1-like complexes to target genes via interactions mediated by its RAWUL domain, notably forming complexes with BCOR and KDM2B, which contribute to gene silencing through histone H2A monoubiquitination and H3K36 demethylation[1][3][4]. Its biological functions implicate PCGF1 in embryonic development, maintenance of pluripotency, cell cycle control, and cancer progression by regulating genes such as BCL6 and CDKN1A[2][4]. Diseases associated with mutations or dysregulation of PCGF1 include developmental disorders and cancer, reflecting its pivotal role in gene expression and cellular homeostasis[2][3].

Other names

NSPC1RNF68Nervous system Polycomb-1RING finger protein 682010002K04RikRNF3A-2MGC10882

Recruitment and assembly of multiprotein PRC1-like complexes; Monoubiquitination of histone H2A leading to gene silencing; Interaction with co-repressors (e.g., BCOR, KDM2B)