Polycomb group RING finger protein 3 (PCGF3)

Polycomb group RING finger protein 3 (PCGF3) is a protein-coding gene that encodes a core subunit of non-canonical Polycomb repressive complex 1 (PRC1)-like complexes. These multi-subunit complexes regulate gene expression via chromatin remodeling and epigenetic histone modification, notably monoubiquitination of histone H2A at lysine 119 (H2AK119ub1). PCGF3 plays important roles in the maintenance of transcriptionally repressive states for target genes during development, including X chromosome inactivation in females. Beyond its canonical function as a transcriptional repressor, recent evidence indicates that PCGF3 (along with PCGF5) also acts as a transcriptional activator in embryonic stem cells, collaborating with the pluripotency factor Tex10 and co-activator p300 to regulate genes involved in mesoderm differentiation. Mutations in PCGF3 have been associated with Shukla-Vernon Syndrome and autism spectrum disorders, and dysregulation of PRC1 components is implicated in various cancers. There are currently no direct pharmacologic agents targeting PCGF3, nor are specific biomarkers or safety concerns documented for its inhibition or modulation.

Other names

Polycomb group RING finger protein 3PCGF3RNF3RNF3AFLJ36550DONG1MGC40413RING finger protein 3Aring finger protein 3

Not applicable; no drugs directly reported as targeting PCGF3; mechanistically, PCGF3 regulates gene expression via chromatin modification and protein-protein interactions