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Target intelligence / Profile preview
Polycomb Repressive Complex 2 (PRC2)
- Target
- PRC2
- Molecular classification
- Multi-protein complex, Histone modification, Histone methyltransferase
01
Overview
Polycomb Repressive Complex 2 (PRC2) is a multi-protein complex that mediates gene silencing through the methylation of histone H3 at lysine 27 (H3K27me3). It plays crucial roles in development, cell differentiation, and disease. The core complex comprises EZH1/EZH2 (catalytic subunit), SUZ12, and EED. Accessory proteins like RBBP4/7, AEBP2, and JARID2 modulate its activity. PRC2 dysregulation is implicated in cancer and neurodegenerative disorders.
02
Mechanism of action
Inhibition of H3K27 methylation
03
Biological functions
Gene silencingEpigenetic regulationDevelopmental regulationStem cell maintenanceX chromosome inactivationGenomic imprintingDNA damage response
04
Disease associations
CancerNeurodegenerative disease (e.g., Alzheimer's disease)
05
Safety considerations
Potential for off-target effects due to widespread gene regulationDevelopmental toxicity
06
Biomarkers
H3K27me3 levels
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