Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Polycystic Kidney Disease 1
- Molecular classification
- Integral membrane protein, Receptor
01
Overview
The PKD1 gene encodes polycystin-1, a large integral membrane protein involved in regulating cell growth, division, migration, and intercellular interactions. It plays a critical role in sensing fluid flow within renal tubules and maintaining intracellular calcium homeostasis. Mutations in PKD1 cause autosomal dominant polycystic kidney disease (ADPKD).
- Other names
- PBPPC-1TRPP1
02
Mechanism of action
Modulation of polycystin-1 and polycystin-2 interaction
03
Biological functions
Regulation of cell growthCell division (proliferation)Cell migrationIntercellular interactionsFluid flow sensingCalcium homeostasisSignal transduction
04
Disease associations
Autosomal Dominant Polycystic Kidney Disease (ADPKD)Chronic Kidney DiseaseTumor suppressor (potential)
05
Safety considerations
Potential for off-target effects due to broad expressionChallenges in selectively targeting renal epithelial cells
Beyond the preview
Go deeper on Polycystic Kidney Disease 1.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Polycystic Kidney Disease 1.