Polycystic kidney disease protein 1-like 3 (PKD1L3)

Polycystic kidney disease protein 1-like 3 (PKD1L3) is an ion channel-forming subunit, belonging to the polycystin protein family, encoded by the human PKD1L3 gene[3][2]. It contains 11 transmembrane domains, a GPCR-like proteolytic site (GPS domain), and a PLAT domain. PKD1L3 typically co-assembles as a single subunit with three PKD2L1 (TRPP3) subunits to form a heterotetrameric, non-selective cation channel that is permeable to calcium, sodium, potassium, and magnesium ions[1][3]. This complex is primarily activated by acid (low extracellular pH) or transient exposure to external calcium, and is essential for detecting and mediating sour taste (acid) signals in type III gustatory cells[2][1][3]. Functionally, PKD1L3 plays a key regulatory role in acid sensing and is considered part of the mechanosensation and chemosensation apparatus in specific tissues. While it is related to the polycystic kidney disease gene family, PKD1L3’s major characterized physiological role is outside of the kidney, particularly in the gustatory system, with disease associations remaining limited or indirect[2][3]. No approved drugs, known interacting drugs, or clinical biomarkers directly target this channel as of the latest data[2][3]. Key Notes: - Canonical function centers on ion channel assembly and sensory perception, not as a classical drug target. - No current evidence for direct pharmacological modulation, biomarker use, or major therapeutic safety challenges described.

Other names

Polycystin-1-like protein 3PKD1L3Polycystin-1L3PC1-like 3 proteinPolycystic kidney disease 1-like 3polycystic kidney disease protein 1-like 3polycystin-1L3