Target intelligence / Profile preview

Polycystin-1 (PC1)

Target: PC1
Molecular classification: Integral membrane glycoprotein, Receptor, Mechanosensor, Ion channel subunit (potential)

Overview

Polycystin-1 (PC1), encoded by the PKD1 gene, is a large transmembrane glycoprotein primarily known for its role in autosomal dominant polycystic kidney disease (ADPKD). It functions as a mechanosensor on primary cilia, regulating intracellular calcium homeostasis via interaction with polycystin-2 (PC2). PC1 influences cell proliferation, differentiation, migration, and cell-cell/matrix interactions, and is essential for renal tubular development. Mutations in PKD1 lead to cystogenesis and ADPKD.

Other names: PKD1Pc-1PBPTRPP1

Mechanism of action

N/A

Biological functions

MechanosensationSignal transductionCalcium homeostasis regulationCell proliferation regulationCell differentiation regulationCell migration regulationCell-cell adhesionCell-matrix interactionsRenal tubular development

Disease associations

Autosomal Dominant Polycystic Kidney Disease (ADPKD)

Safety considerations

Targeting PC1 directly may have pleiotropic effects due to its diverse functions.

Biomarkers

PC1 expression levels (potential biomarker for ADPKD severity/progression)

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