Polycystin 1, transient receptor potential channel interacting pseudogene 6 (PKD1P6)

PKD1P6 is a pseudogene highly homologous to the functional PKD1 gene, which encodes polycystin-1—a membrane protein involved in mechanosensation and associated with autosomal dominant polycystic kidney disease (ADPKD)[5]. PKD1P6 itself does not encode a protein and has no known functional protein product or therapeutic targeting relevance. It exists in a gene cluster with other PKD1 pseudogenes on chromosome 16p, reflecting genome duplication events[5]. While PKD1 (not PKD1P6) is causally implicated in kidney disease, PKD1P6 is only important as a genomic artifact with no direct biological or clinical function.

Other names

HG6GPSPLAT and transmembrane domain-containing proteinpolycystic kidney disease 1 (autosomal dominant) pseudogene 6PKD1P6