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Target intelligence / Profile preview
Polycystin-2 (PC2)
- Target
- PC2
- Molecular classification
- Ion channel, TRP channel, Non-selective cation channel
01
Overview
Polycystin-2 (PC2), also known as TRPP2, is a non-selective cation channel encoded by the PKD2 gene. It is an integral membrane protein that regulates calcium ion influx across cellular membranes. PC2 functions in complex with polycystin-1 (PC1) and is crucial for kidney development and function. Mutations in PKD2 cause autosomal dominant polycystic kidney disease (ADPKD).
- Other names
- TRPP2PKD2
02
Mechanism of action
Modulation of calcium ion influx through PC2 channels.
03
Biological functions
Calcium signalingRegulation of intracellular calcium homeostasisCell proliferationCell migrationCell differentiationIon transportRegulation of fluid secretion
04
Disease associations
Autosomal dominant polycystic kidney disease (ADPKD)
05
Safety considerations
Off-target effects on other TRP channelsPotential for electrolyte imbalances due to altered calcium homeostasis
06
Interacting drugs
La³⁺
3 more in the full profile.
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