Polycystin-2-like 1 ion channel (PKD2L1)

Polycystin-2-like 1 ion channel (PKD2L1) is a member of the TRP (transient receptor potential) ion channel superfamily, specifically the TRPP subfamily, encoded by the PKD2L1 gene. This protein forms a homotetrameric ion channel structure typical of TRP channels, featuring six transmembrane segments and a polycystin mucolipin domain. PKD2L1 is permeable to calcium and monovalent cations and is mainly localized to the primary cilia and plasma membrane of various cell types, where it participates in modulating ciliary calcium signaling and electrical activity. PKD2L1 shares significant sequence identity with polycystin-2 (PKD2), the product of which is implicated in autosomal dominant polycystic kidney disease (ADPKD), but unlike PKD2, no human diseases have been conclusively linked to PKD2L1 mutations. Functional studies in mice have shown that deletion of PKD2L1 leads only to mild developmental phenotypes. PKD2L1 is essential for specific calcium-dependent signaling in primary cilia and may contribute to chemosensation in certain neurons, like cerebrospinal fluid-contacting neurons[1][3]. No known drugs or selective modulators currently target this channel, and its value as a therapeutic target is currently considered exploratory.

Other names

Polycystin-2-like protein 1PKD2L1PKD2LPKDLTRPP3Polycystin-2L1PCLPolycystic kidney disease 2-like 1 proteinPolycystin-2 homologPolycystin-LPolycystin-L1transient receptor potential cation channel, subfamily P, member 3