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Polycystin family receptor for egg jelly (PKDREJ)
- Target
- PKDREJ
- Molecular classification
- Receptor, Ion channel (related to polycystin family, with putative channel-like features), Polycystin protein family
01
Overview
Polycystin family receptor for egg jelly (PKDREJ) is a testis-specific protein in humans encoded by the PKDREJ gene. It is a member of the polycystin family, characterized by 11 transmembrane domains, a receptor for egg jelly (REJ) domain, a G-protein-coupled receptor proteolytic site (GPS) domain, and a polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain. PKDREJ is believed to act as a sperm surface receptor for egg zona pellucida glycoproteins, crucial for sperm-egg recognition and regulating the timing of acrosome exocytosis, a process essential for fertilization. While gene paralogs in the polycystin family are implicated in kidney diseases such as polycystic kidney disease, PKDREJ itself is primarily linked to reproductive function, with potential but unproven roles in human fertility and related genetic disorders. There are no known drugs directly targeting PKDREJ, and its therapeutic targeting remains largely unexplored[1][2][4][5][6].
- Other names
- PKD and REJ homologPolycystic kidney disease and receptor for egg jelly-related proteinPolycystin (PKD) family receptor for egg jellyPolycystic kidney disease (polycystin) and REJ homolog (sperm receptor for egg jelly homolog, sea urchin)Polycystic kidney disease (polycystin) and REJ (sperm receptor for egg jelly, sea urchin homolog)-likePKDRE
02
Biological functions
Sperm-egg recognition (specifically binding to egg zona pellucida glycoproteins)Regulation of acrosome exocytosis in spermRegulation of sperm transportParticipation in reproductive processesCalcium ion binding and channel activity
03
Disease associations
Polycystic kidney disease (family relation/paralog associated, but not PKDREJ directly)Reproductive disorders (implicated in infertility or abnormal fertilization processes)Kidney disease (family linkage/paralog association)
04
Safety considerations
Low tissue specificity outside reproductive systemUnknown off-target effects for potential drug targetingLimited clinical data
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