Target intelligence / Profile preview

Polyethylene Glycol (PEG)

Target: PEG
Molecular classification: Polyether, Polymer, Excipient

Overview

Polyethylene glycol (PEG) is a synthetic, hydrophilic polyether compound. It is used in a variety of applications, including as an osmotic laxative, a surfactant, and a drug delivery vehicle. Its tunable physical properties based on chain length/molecular weight enable broad utility across pharmaceutical formulations as well as industrial processes. Its safety profile and chemical inertness make it especially valuable where biocompatibility is required.

Other names: Polyethylene oxidePEOPolyoxyethylenePOE

Mechanism of action

Acts osmotically by retaining water in the stool through hydrogen bonding, softening stools and increasing bowel movement frequency.

Biological functions

Osmotic agentSurfactantEmulsifierHumectantDrug delivery vehiclePassivation agent

Disease associations

Constipation

Safety considerations

Combustible; decomposes above 50°C to release organic compounds and potentially noxious gases.Potential allergic reactions

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