Target intelligence / Profile preview

Polyhistidine Triad Protein D (PhtD)

Target: PhtD
Molecular classification: Protein, Surface-exposed protein

Overview

Polyhistidine triad protein D (PhtD) is a surface-exposed protein found in Streptococcus pneumoniae and other streptococci. It is characterized by multiple histidine-rich HxxHxH motifs. PhtD plays a crucial role in zinc homeostasis, immune evasion by interfering with complement deposition, and adherence to host cells. It is considered an important vaccine candidate against S. pneumoniae.

Mechanism of action

Not applicable; target for vaccine development.

Biological functions

Zinc ion homeostasisZinc ion bindingImmune evasionAdherenceComplement inhibitionVirulence

Disease associations

Infection

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