Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Polyhomeotic-like protein 1 (PHC1)
- Target
- PHC1
- Molecular classification
- Epigenetic regulator, Polycomb group protein, Component of Polycomb repressive complex 1 (PRC1), Chromatin-associated protein, Other
01
Overview
Polyhomeotic-like protein 1 (PHC1) is a chromatin-associated protein encoded by the PHC1 gene in humans and is a conserved member of the Polycomb group (PcG) of proteins[1][3]. PHC1 acts as a core component of the Polycomb repressive complex 1 (PRC1), which regulates gene expression via chromatin remodeling and histone modification, particularly by monoubiquitination of histone H2A at lysine 119[3]. This epigenetic silencing is crucial for maintaining transcriptional repression of key developmental genes, including Hox genes, thus ensuring proper development and stem cell maintenance[3][2]. PHC1 mutations cause primary microcephaly and can impair DNA repair mechanisms[3][4]. PcG proteins, including PRC1 complexes with PHC1, are implicated in the control of cell fate, proliferation, and differentiation, and their dysregulation is associated with cancer and a range of neurodevelopmental disorders[2][3].
- Other names
- Polyhomeotic homolog 1PHC1EDR1PH1hPH1HPH1RAE28Early development regulatory protein 1MCPH11early development regulator 1 (homolog of polyhomeotic 1)polyhomeotic-like 1
02
Biological functions
Chromatin remodelingRegulation of gene expressionHistone modification (monoubiquitination of histone H2A Lys119)Maintenance of transcriptional repression (particularly of Hox genes)Regulation of cell proliferation and senescenceControl of neural developmentDNA binding and protein-protein interaction
03
Disease associations
CancerPrimary autosomal recessive microcephaly (including Microcephaly 11)Impaired DNA repairOther developmental disorders
04
Safety considerations
Potential for developmental toxicity (deficiency causes microcephaly)Possible roles in tumorigenicity if dysregulated
05
Biomarkers
PHC1 mutations as biomarkers for primary microcephalyExpression changes as potential markers in cancer or developmental disorders
Beyond the preview
Go deeper on Polyhomeotic-like protein 1 (PHC1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Polyhomeotic-like protein 1 (PHC1).