Polyhomeotic-like protein 3 (PHC3)

Polyhomeotic-like protein 3 (PHC3) is a member of the Polycomb group protein family, acting as a component of the human Polycomb repressive complex 1 (PRC1)-related hPRC-H complex, mediating gene silencing through epigenetic regulation. PHC3 contains a (Cys)4-type zinc finger and a sterile alpha motif (SAM) domain, both important for protein-protein interactions involved in organizing higher-order chromatin structure and recruiting chromatin-remodeling complexes. PHC3 regulates the repression of transcription in quiescent (G₀) cells, interacting with other Polycomb proteins (such as YY1, M33, and Bmi1) and the transcription factor E2F6, with which it forms complexes that silence E2F and Myc target promoters. Loss-of-function mutations, loss of expression, and deletion of the PHC3 gene have been linked to human osteosarcoma, suggesting its role as a tumor suppressor gene. There is no current evidence for direct pharmacological targeting of PHC3, but its loss serves as a potential biomarker for predisposition to or progression of certain cancers[1][2][3].

Other names

EDR3PH3hPH3FLJ12967FLJ12729HPH3Early development regulatory protein 3Homolog of polyhomeotic 3early development regulator 3polyhomeotic like 3polyhomeotic-like protein 3