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Target intelligence / Profile preview
Polymerase Acidic Protein Endonuclease Domain (PA-N)
- Target
- PA-N
- Molecular classification
- Enzyme, Endonuclease, Viral Protein
01
Overview
The polymerase acidic (PA) protein endonuclease domain is a critical component of the influenza virus RNA-dependent RNA polymerase complex, located at the N-terminus of the PA protein. Its primary function is to cleave host pre-mRNAs to generate capped RNA primers via "cap-snatching," which the viral polymerase then uses to initiate synthesis of viral mRNAs. This activity is essential for both transcription and replication of the influenza virus genome. The PA endonuclease is a validated antiviral drug target.
- Other names
- PA Endonuclease DomainPANPA N-terminal domainInfluenza PA-N
02
Mechanism of action
Inhibition of PA endonuclease activity
03
Biological functions
Cap-snatchingmRNA cleavageViral mRNA synthesisViral genome transcriptionViral genome replication
04
Disease associations
InfectionInfluenza
05
Safety considerations
Resistance mutations (e.g., I38T, E23G/K) can reduce drug susceptibility.
06
Interacting drugs
Baloxavir marboxil (BXM)
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