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Polymerase Theta Helicase (None)
- Target
- None
- Molecular classification
- Enzyme, Helicase, DNA Polymerase, Superfamily II Helicase, Ski2-like family Helicase
01
Overview
Polymerase theta helicase (Polθ helicase) is a specialized domain within the DNA polymerase theta (Polθ, gene symbol POLQ), an enzyme critical for theta-mediated end joining (TMEJ). It is a superfamily II helicase, playing a role in DNA binding and annealing at double-strand breaks to facilitate error-prone DNA repair via microhomology search. It is upregulated in some cancers, making it a potential therapeutic target.
- Other names
- POLQ HelicasePolθ HelicasePOLQ-HLDPolymerase theta helicase domain
02
Mechanism of action
Inhibition of helicase and/or polymerase activity; disruption of TMEJ
03
Biological functions
ATP hydrolysisDNA bindingDNA annealingMicrohomology-mediated DNA repairTheta-mediated end joining (TMEJ)
04
Disease associations
CancerGenome instability
05
Safety considerations
Potential for off-target effects on other DNA repair pathwaysToxicity due to disruption of DNA replication/repairPossible development of resistance
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