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Polymorphonuclear cell oxidative burst
- Molecular classification
- Biological Process
01
Overview
Rapid increase in ROS production by PMNs crucial for pathogen killing but potentially damaging to host tissues. It involves the activation of the NADPH oxidase complex, which catalyzes the reduction of oxygen to superoxide.
- Other names
- Neutrophil oxidative burstPMN oxidative burstRespiratory burst
02
Mechanism of action
Varies depending on the modulator; e.g., PMA activates protein kinase C, enhancing NADPH oxidase activity; DPI inhibits NADPH oxidase.
03
Biological functions
Immune responsePathogen killingReactive oxygen species production
04
Disease associations
InfectionInflammationChronic granulomatous disease (CGD)
05
Safety considerations
Collateral tissue damageInflammation
06
Interacting drugs
Phorbol myristate acetate (PMA)
1 more in the full profile.
07
Biomarkers
ROS levelsSuperoxide productionNADPH oxidase activity
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