Polymorphonuclear Myeloid-Derived Suppressor Cell (PMN-MDSC)

Polymorphonuclear myeloid-derived suppressor cells are pathologically activated neutrophil-lineage cells central to tumor-induced immune suppression. They exert multifaceted inhibitory effects on adaptive immunity through metabolic disruption, cytokine production, lipid transfer affecting dendritic cell function—and promote metastasis via tissue remodeling enzymes. Their unique surface marker profile—including emerging targets like CD300ld—makes them attractive candidates for selective therapeutic intervention aimed at improving outcomes in oncology patients resistant to current treatments.

Other names

Myeloid-Derived Suppressor Cell (PMN-MDSC subtype)Pathologically activated neutrophilsN2-like Tumor-Associated Neutrophils (TANs)CD11b+ CD14- CD15+ cellsCD11b+ Ly6G+ Ly6C^lo cells

Inhibition of T cell, B cell, and NK cell functions through production of ROS, high arginase activity, induction of endoplasmic reticulum stress response, secretion of immunosuppressive cytokines, degradation of the endothelial barrier via secretion of matrix metalloproteinases (MMPs), induction of NETosis, and support for cancer cell motility.