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Target intelligence / Profile preview
Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11)
- Target
- GALNT11
- Molecular classification
- Enzyme, Glycosyltransferase
01
Overview
Polypeptide N-acetylgalactosaminyltransferase 11 (GALNT11) is an enzyme that initiates protein O-linked glycosylation by transferring N-acetyl-D-galactosamine to serine or threonine residues of polypeptides, a key step in forming O-glycans[2][3][4]. GALNT11 localizes to the Golgi apparatus and specifically regulates left-right embryonic patterning by mediating glycosylation of the NOTCH1 receptor, which modulates Notch signaling activity[1][2]. This activity influences the balance and identity of motile and immotile cilia at the left-right organizer during development, and disruptions of GALNT11 (by mutation or deficiency) are associated with congenital heart diseases such as heterotaxy and right atrial isomerism[1][2]. GALNT11 acts as a critical developmental regulator and is a member of the polypeptide N-acetylgalactosaminyltransferase family of glycosyltransferase enzymes.
- Other names
- GalNAc-T11pp-GaNTase 11Polypeptide GalNAc transferase 11Protein-UDP acetylgalactosaminyltransferase 11UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11GALNAC-T11GALNACT11
02
Mechanism of action
Not applicable (no drugs listed)
03
Biological functions
Protein O-linked glycosylation via threonine and serine residuesInitiation of O-glycosylation of proteinsRegulation of Notch signalingMediation of left/right embryonic axis formation (especially via cilia identity and function)
04
Disease associations
Congenital heart diseaseHeterotaxy (left-right patterning disorder)Right atrial isomerismOther (may include further disorders involving Notch pathway dysregulation)
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