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Polypeptide N-acetylgalactosaminyltransferase 14 (GALNT14)

Target: GALNT14
Molecular classification: Enzyme, Glycosyltransferase

Overview

Polypeptide N-acetylgalactosaminyltransferase 14 is a Golgi-resident enzyme that catalyzes the first step in O-glycosylation by transferring N-acetyl-D-galactosamine (GalNAc) to serine or threonine residues on peptide substrates. It is a member of the polypeptide N-acetylgalactosaminyltransferase family and is especially active on mucin-derived peptides such as Muc2, Muc5AC, Muc7, and Muc13. Variants in the GALNT14 gene have been implicated in cancer progression and differential responses to chemotherapy, particularly in liver cancer.

Other names: Polypeptide GalNAc Transferase 14GalNAc-T14GalNAc-T10UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 14Protein-UDP Acetylgalactosaminyltransferase 14

Biological functions

O-glycosylation of proteinsTransfer of N-acetyl-D-galactosamine to serine or threonine residuesModification of mucin-type proteinsPotential involvement in regulation of protein function

Disease associations

Cancer (including roles in cancer progression and chemotherapy response, notably in hepatocellular carcinoma and prostate rhabdomyosarcoma)Congenital Central Hypoventilation Syndrome

Biomarkers

Single nucleotide polymorphisms (SNPs) in GALNT14 are associated with chemotherapy response in advanced hepatocellular carcinoma

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