Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15)

Polypeptide N-acetylgalactosaminyltransferase 15 (GALNT15) is an enzyme that catalyzes the initial step in O-linked oligosaccharide biosynthesis by transferring an N-acetyl-D-galactosamine residue from UDP-GalNAc to serine or threonine residues on polypeptide substrates. It shows broader substrate specificity toward mucin peptides, such as Muc1a and Muc5AC, but has lower transferase activity compared to related family members. GALNT15 is part of the large family of polypeptide N-acetylgalactosaminyltransferases that regulate mucin-type O-glycosylation—a modification important in extracellular matrix structure, cell signaling, and protein stability. Mutations or dysregulation may be associated with certain diseases, including classic Ehlers-Danlos syndrome.

Other names

GALNT15GALNTL2GALNT7UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 15UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase-like protein 2Polypeptide N-acetylgalactosaminyltransferase-like protein 2Protein-UDP acetylgalactosaminyltransferase-like protein 2Polypeptide GalNAc transferase-like protein 2Polypeptide GalNAc transferase 15Pp-GalNAc-T15Pp-GaNTase-like protein 2GalNAc-T-like protein 2UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 7Pregnancy-induced hypertension syndrome-related protein 5Polypeptide N-acetylgalactosaminyltransferase 13UDP-GalNAc transferase T15EC 2.4.1.41GALNACT15GALNT13PIH5