Polyphenol-mediated antioxidant activity

Polyphenol-mediated antioxidant activity refers to the collective antioxidant effects exerted by diverse polyphenol compounds found in plant foods. These activities include direct scavenging of free radicals (ROS, RNS), chelating transition metals to prevent catalytic radical generation, inhibiting oxidative enzymes, and upregulating cellular antioxidant defenses through modulation of key signaling pathways such as NF-κB and Nrf2. These mechanisms contribute to the reduction of oxidative stress and inflammation. Regular dietary intake of polyphenol-rich foods is associated with a reduced risk of chronic diseases, including cardiovascular disease, neurodegenerative disorders, metabolic syndromes, and cancers[1][2][3][4]. However, "polyphenol-mediated antioxidant activity" itself is not a discrete molecular target or protein and thus not suitable as a canonical therapeutic target entry. Key clarification: This entry is not a molecular target, but rather a pharmacological or functional pathway mediated by a large class of dietary or natural products (polyphenols). Any structured database should instead seek specific molecular targets modulated by polyphenols, such as "Nuclear factor erythroid 2-related factor 2 (Nrf2)" or "Nuclear factor kappa B (NF-κB)"[1][2][3][4].

Other names

Polyphenol antioxidant effectPolyphenol antioxidant pathwayPolyphenol redox activity

Free radical scavenging, Chelation of transition metal ions, Inhibition of oxidases (e.g., COX, LOX), Upregulation of antioxidant enzymes (e.g., SOD, catalase, GPx), Modulation of signaling pathways (e.g., inhibition of NF-κB, activation of Nrf2, PI3K/Akt)