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Target intelligence / Profile preview
Polyribosyl-ribitol phosphate capsular polysaccharide of Haemophilus influenzae type b (PRP)
- Target
- PRP
- Molecular classification
- Polysaccharide
01
Overview
The polyribosyl-ribitol phosphate (PRP) capsular polysaccharide of Haemophilus influenzae type b is a high-molecular-weight polymer composed of repeating units of D-ribitol and D-ribose linked by phosphate groups. It plays a crucial role as a virulence factor by protecting the bacterium from host immune responses, particularly phagocytosis and complement-mediated lysis. The PRP polysaccharide is used in conjugate vaccines to induce an immune response against Hib, thereby preventing invasive Hib diseases like meningitis and sepsis, especially in children under five years old.
- Other names
- Polyribosyl ribitol phosphatePRP capsular polysaccharide
02
Mechanism of action
Conjugated vaccines induce immune response by providing a T-cell-dependent immune response
03
Biological functions
Virulence factorImmune evasionProtection against host defenses
04
Disease associations
InfectionMeningitisSevere infections in infants and children
05
Safety considerations
Generally safe when used in conjugate vaccinesPotential for allergic reactions as with any vaccine
06
Interacting drugs
Conjugate vaccines that include PRP as an antigen
07
Biomarkers
Antibodies against PRP are protective biomarkers
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