POM121 transmembrane nucleoporin-like 12 (POM121L12)

POM121 transmembrane nucleoporin-like 12 (POM121L12) is a member of the nucleoporin family, classified as a transmembrane glycoprotein and a predicted structural component of the nuclear pore complex (NPC)[2][4][6]. It shares similarity with the canonical POM121 protein, which is an essential membrane-anchored nucleoporin necessary for the assembly and function of NPCs, mediating regulated transport between the nucleus and cytoplasm[4][6]. The specific biological functions and disease associations of POM121L12 remain largely uncharacterized, but gene ontology annotations indicate it likely contributes structurally to the NPC[4]. No validated roles as a therapeutic target, nor evidence for interacting drugs, biomarker utility, or specific safety concerns, have been described for POM121L12[2][4][6][8]. While perturbations in POM121L12 gene expression have been noted across diverse datasets, this reflects general functional association data and does not suggest a defined therapeutic application[2].

Other names

POM121-like protein 12DKFZp564N2472POM121 membrane glycoprotein-like 12P1L12_HUMAN