Pomalidomide

Pomalidomide is an immunomodulatory drug (IMiD) and thalidomide analogue used in the treatment of multiple myeloma and Kaposi's sarcoma. It acts through multiple mechanisms, including immunomodulation, anti-inflammatory effects, antiangiogenesis, and induction of apoptosis in malignant plasma cells. It also binds to cereblon, leading to degradation of specific transcription factors. Due to its teratogenic potential, strict pregnancy prevention programs are required.

Other names

PomalystImnovid

Immunomodulation, enhances T-cell and natural killer (NK) cell activity, increasing anti-tumor immune responses; anti-inflammatory effects, inhibits proinflammatory cytokines; antiangiogenic effects, inhibits angiogenesis; antiproliferative effects & apoptosis induction, induces apoptosis in malignant plasma cells; Cereblon E3 ligase modulation, leads to degradation of specific transcription factors involved in cancer cell survival.