POPDC1 antisense RNA 1 (POPDC1-AS1)

POPDC1 antisense RNA 1 (POPDC1-AS1) is a long non-coding RNA transcribed antisense to the POPDC1 (BVES) gene, located on chromosome 6q21[1][5]. It is part of the class of antisense lncRNAs, which can regulate the expression of their sense gene partners by various mechanisms, including influencing mRNA stability, transcription, or chromatin modification[2][9]. POPDC1-AS1 has been identified as downregulated in colorectal adenocarcinoma, suggesting a role in tumor suppression and a possible functional synergy with other lncRNAs and genes involved in cancer development and progression[3]. The specific mechanistic details and clinical utility of POPDC1-AS1 remain under investigation, and it is not currently considered a direct therapeutic target, druggable entity, or established biomarker in clinical use[3][5]. - POPDC1-AS1 is a non-coding RNA, not a protein or classic drug target such as a receptor or enzyme. - Its biological and disease relevance appears to be predominantly through gene regulation (especially of the adjacent POPDC1/BVES gene, which is itself involved in cell adhesion and tumor suppression)[3][5][7]. - There is no evidence that any drugs directly target POPDC1-AS1, nor established mechanisms of action for therapeutics directed at it. - Most functions and disease associations are inferred from limited cancer expression data and regulatory relationships, not from established biochemical pathway mapping or therapies.

Other names

C6orf112bA99L11.2BVES antisense RNA 1BVES antisense gene protein 1BVES-AS1POPDC1-AS1 (non-protein coding)