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Target intelligence / Profile preview
PorA Outer Membrane Vesicle Protein P1.4 (PorA P1.4)
- Target
- PorA P1.4
- Molecular classification
- Porin, Outer membrane protein
01
Overview
PorA outer membrane vesicle protein P1.4 is a trimeric beta-barrel porin from *N. meningitidis*, crucial for solute transport across the bacterial outer membrane while serving as a dominant surface antigen recognized by the human immune system—especially when delivered via natural or engineered OMVs for vaccine purposes.
- Other names
- PorAOMV protein P1.4Neisseria meningitidis PorA P1.4
02
Mechanism of action
Vaccine antigen; elicits antibody-mediated immunity
03
Biological functions
Passive transportImmune responseAdhesionComplement activationNutrient uptake
04
Disease associations
InfectionMeningococcal disease
05
Safety considerations
Potential for serotype replacement after vaccinationLimited coverage of all meningococcal strains
06
Biomarkers
Antibody titers against PorA P1.4 (vaccine efficacy)
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