Porcine adaptive immune system responding to PRRSV, PCV2, and Mycoplasma hyopneumoniae antigens

The porcine adaptive immune system's response to PRRSV, PCV2, and Mycoplasma hyopneumoniae antigens represents a complex physiological process rather than a single molecular target. This response involves the coordinated action of antigen-presenting cells, B-lymphocytes, and T-lymphocytes to recognize and eliminate these specific pathogens, which are the primary drivers of the Porcine Respiratory Disease Complex (PRDC) (Opriessnig et al., 2007). PRRSV is particularly noted for its ability to interfere with innate signaling and delay the onset of neutralizing antibodies and cell-mediated immunity (Lunney et al., 2016). PCV2 infection can lead to lymphoid depletion, further complicating the host's ability to mount an effective adaptive response (Gillespie et al., 2009). Mycoplasma hyopneumoniae acts as an immunomodulator that enhances the severity of PRRSV and PCV2 infections by recruiting inflammatory cells to the lungs (Thacker et al., 1999). Therapeutic strategies typically involve multivalent vaccines designed to elicit protective immunity against all three pathogens simultaneously, though the efficacy of these interventions depends on the specific strains involved and the timing of administration.

Other names

Porcine Respiratory Disease Complex (PRDC) immune responseSwine adaptive immunity to PRRSV, PCV2, and M. hyoPorcine immune response to respiratory co-infections

Induction of pathogen-specific humoral and cellular immune responses through active immunization with viral or bacterial antigens.