Target intelligence / Profile preview

Porcine Protein Allergens

Molecular classification
Serum Albumin, Carbohydrate Epitope, Protein
01

Overview

Porcine protein allergens are proteins derived from pigs (Sus scrofa) that can trigger allergic reactions in sensitized individuals. The most significant allergens identified in pork are Sus s 1 (porcine serum albumin) and the carbohydrate epitope alpha-gal (galactose-α-1,3-galactose). These proteins can cause a range of allergic responses, from mild skin symptoms to severe anaphylaxis. Management primarily involves strict avoidance of pork and products containing porcine-derived ingredients, along with emergency preparedness for anaphylactic reactions.

Other names
Sus scrofa allergensPork allergensSus s 1 (Porcine Serum Albumin)Alpha-GalGalactose-alpha-1,3-galactose
02

Mechanism of action

Epinephrine acts as an emergency treatment for anaphylaxis by reversing symptoms like bronchoconstriction and hypotension.

03

Biological functions

Immune response elicitationAllergic reaction induction
04

Disease associations

Pork allergyAlpha-Gal SyndromePork-Cat SyndromeOccupational allergy
05

Safety considerations

AnaphylaxisCross-reactivity with other mammalian allergensDelayed allergic reactions (Alpha-Gal Syndrome)
06

Interacting drugs

Epinephrine
07

Biomarkers

Specific IgE antibodies against pig allergensSpecific IgE antibodies against cat allergens (for Pork-Cat Syndrome)Alpha-Gal IgE antibodies

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