Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Porcupine protein (PORCN)
- Target
- PORCN
- Molecular classification
- Enzyme, Membrane-bound O-acyltransferase
01
Overview
Porcupine protein (PORCN) is an endoplasmic reticulum-resident O-acyltransferase essential for the palmitoleoylation, secretion, and activity of all mammalian Wnt proteins. It plays a critical role in Wnt signaling pathways, which are involved in embryonic development, tissue renewal, differentiation, and homeostasis. Mutations in the *PORCN* gene are associated with developmental disorders such as Focal Dermal Hypoplasia (FDH)/Goltz-Gorlin Syndrome. PORCN is a therapeutic target, and small-molecule inhibitors are being developed to modulate Wnt signaling in cancer and other diseases.
- Other names
- DHOFFODHMG61MGC29687porcupine homolog (Drosophila)porcupine O-acyltransferase
02
Mechanism of action
Inhibition of PORCN catalytic activity, preventing Wnt protein palmitoleoylation and secretion/activation.
03
Biological functions
Protein lipidationWnt signaling regulationProtein secretionEmbryonic developmentTissue renewalCell differentiationHomeostasis
04
Disease associations
Focal Dermal Hypoplasia (FDH)/Goltz-Gorlin SyndromeColobomaCancer
05
Safety considerations
Embryonic lethality with complete loss-of-functionPotential developmental abnormalities due to Wnt signaling disruption
06
Interacting drugs
LGK974 (WNT974)
2 more in the full profile.
Beyond the preview
Go deeper on Porcupine protein (PORCN).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Porcupine protein (PORCN).