Porosome-associated proteins

The porosome is a cup-shaped supramolecular nanomachine located at the plasma membrane of eukaryotic cells, serving as the universal machinery for cell secretion. It consists of a complex assembly of proteins, including SNAREs, ATPases, and ion channels, which facilitate the docking and transient fusion of secretory vesicles for the fractional release of intra-vesicular contents. Malfunctions in porosome-associated proteins are linked to a variety of secretory disorders, such as Cystic Fibrosis, where defective CFTR-porosome interactions lead to impaired mucus clearance, and Alzheimer's disease, where beta-amyloid disrupts neurosecretion. Therapeutic strategies like TLG-FT101 target these associated proteins to restore the structural and functional integrity of the secretory portal. By modulating the assembly or activity of the porosome complex, these drugs aim to treat the root cause of diseases characterized by secretory dysfunction rather than merely managing symptoms.

Other names

Secretory portalPorosome complexCellular secretory machineryNeuronal porosomeExocytosome

Modulation of porosome-associated protein interactions to restore or normalize secretory machinery function and cellular hydration.