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Target intelligence / Profile preview
Porphyromonas gingivalis (P. gingivalis)
- Target
- P. gingivalis
- Molecular classification
- Bacterium, Gram-negative bacterium, Anaerobe
01
Overview
Porphyromonas gingivalis is a Gram-negative, anaerobic bacterium implicated as a keystone pathogen in chronic periodontitis and linked to several systemic diseases. It possesses multiple virulence factors that contribute to tissue destruction and immune evasion, promoting inflammation and dysbiosis in the oral cavity. It is not a direct therapeutic target in the same way a receptor or enzyme would be, but rather an infectious agent that can be targeted with antibiotics or other antibacterial strategies.
- Other names
- Bacteroides gingivalisBacteroides melaninogenicus
02
Mechanism of action
N/A
03
Biological functions
Amino acid fermentationBiofilm formationImmune modulationTissue degradationAdhesionProteolysis
04
Disease associations
Chronic periodontitisAtherosclerosisAlzheimer’s diseaseRheumatoid arthritisDiabetes mellitus complicationsAdverse pregnancy outcomesRespiratory diseasesLiver diseasesDepression
05
Safety considerations
Potential for systemic disseminationInduction of dysbiosis in oral microbiomeContribution to inflammatory diseasesAntibiotic resistance
06
Biomarkers
Specific antibodies against P. gingivalis
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