Positively charged proteins in damaged mucosa

Positively charged proteins in damaged mucosa represent a physiological target for cytoprotective agents used in the treatment of acid-peptic disorders (StatPearls, 2023). In conditions such as peptic ulcer disease or erosive gastritis, the protective epithelial layer is breached, exposing underlying proteins like albumin and fibrinogen that carry a net positive charge in the acidic environment of the stomach (PubChem). These proteins serve as an electrostatic anchor for polyanionic drugs like sucralfate, which polymerize into a sticky, gel-like substance (Goodman & Gilman, 2018). This interaction forms a physical barrier over the ulcerated area, shielding the sensitive tissue from aggressive factors including hydrochloric acid, pepsin, and bile acids. By isolating the damaged site, this mechanism facilitates the natural healing process and prevents further erosion of the mucosal lining. While not a single receptor, this collection of proteins is a critical pharmacological target for localized, non-systemic therapy in gastroenterology.

Other names

Exposed proteins in ulcerated mucosaNecrotic tissue proteinsUlcer base proteinsAlbumin and fibrinogen in damaged mucosa

Sucralfate undergoes polymerization in an acidic environment (pH < 4) to form a viscous, negatively charged paste that electrostatically binds to positively charged proteins (such as albumin and fibrinogen) exposed in the damaged mucosa or ulcer base (StatPearls, 2023).