Target intelligence / Profile preview

Postmeiotic segregation increased 1 (PMS1)

Target: PMS1
Molecular classification: Enzyme, DNA mismatch repair mutL/hexB family

Overview

PMS1 encodes a protein that is part of the DNA mismatch repair (MMR) system. It forms heterodimers with MLH1 to correct errors during DNA replication, maintaining genomic stability. Mutations in PMS1 are associated with Lynch syndrome/HNPCC3, increasing the risk of various cancers due to defective DNA mismatch repair.

Other names: HNPCC3hPMS1PMSL1MLH2

Biological functions

DNA mismatch repairGenome maintenanceBase Excision Repair

Disease associations

CancerHereditary nonpolyposis colorectal cancer type 3 (HNPCC3)Endometrial cancerIntestinal cancerStomach cancerLynch syndrome

Safety considerations

Potential for off-target effects in DNA repair pathwaysDevelopment of resistance through alternative repair mechanisms

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