Target intelligence / Profile preview

Postsynaptic Density Protein 95 (PSD-95)

Target: PSD-95
Molecular classification: MAGUK, Scaffolding Protein

Overview

Postsynaptic density protein 95 (PSD-95) is a major scaffolding protein highly enriched at the postsynaptic density of excitatory glutamatergic synapses in the brain. It plays a central role in organizing synaptic signaling complexes, regulating receptor localization, and modulating synaptic plasticity—key processes underlying learning and memory. It interacts with glutamate receptors and other scaffolding proteins.

Biological functions

ScaffoldingSynapse organizationRegulation of synaptic plasticityRegulation of receptor localization

Disease associations

Huntington's diseaseNeurological disorders

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