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Postsynaptic Density Protein 95 PDZ Domain (PSD-95 PDZ Domain)
- Target
- PSD-95 PDZ Domain
- Molecular classification
- Protein Domain, Scaffolding Protein, MAGUK family
01
Overview
The PDZ domains of PSD-95 are protein interaction modules crucial for organizing synaptic signaling complexes at excitatory synapses. PSD-95 contains three PDZ domains (PDZ1, PDZ2, and PDZ3) that bind to specific C-terminal motifs of various synaptic proteins, including neurotransmitter receptors, ion channels, and signaling molecules. These interactions facilitate clustering and anchoring of proteins at postsynaptic sites, regulating synapse strength and plasticity. Dysregulation of PSD-95 PDZ domain function has been implicated in neurological disorders.
- Other names
- SAP-90 PDZ DomainDLG4 PDZ DomainPDZ1 domain of PSD-95PDZ2 domain of PSD-95PDZ3 domain of PSD-95
02
Mechanism of action
Modulation of protein-protein interactions within the postsynaptic density
03
Biological functions
Protein-protein interactionSynapse organizationReceptor clusteringSignal transductionScaffoldingSynaptic plasticity
04
Disease associations
Neurological disordersCognitive impairmentNeurodegenerative disease
05
Safety considerations
Off-target effects due to promiscuity of PDZ domain interactionsDisruption of normal synaptic function
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