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Potassium–transporting ATPase alpha chain 1
- Molecular classification
- Enzyme, ATPase, Ion pump, Transporter
01
Overview
Potassium–transporting ATPase alpha chain 1 is the catalytic subunit of the gastric H+/K+ ATPase pump, responsible for exchanging hydrogen (H+) and potassium (K+) ions across the apical membrane of parietal cells in the stomach. This process is essential for gastric acid production and proper digestion. It is a key target for proton pump inhibitors (PPIs), which are widely used to treat gastroesophageal reflux disease (GERD) and peptic ulcer disease.
- Other names
- Gastric H(+)/K(+) ATPase subunit alphaProton pumpH(+) Pump / H+ PumpATP4A
02
Mechanism of action
Hydrolyzes ATP to transport K+ ions into cells while exporting H+ ions out, creating an acidic environment in the stomach lumen.
03
Biological functions
Acid production in gastric parietal cellsIon transportMaintaining electrochemical gradients
04
Disease associations
HypochlorhydriaAchlorhydriaReflux esophagitisPeptic ulcersHelicobacter pylori infectionsOsteoarthritisRheumatoid arthritis
05
Safety considerations
Potential side effects associated with long-term PPI use
06
Interacting drugs
Proton pump inhibitors (PPIs)
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