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Potassium calcium-activated channel subfamily M alpha member 1 (KCa1.1)
- Target
- KCa1.1
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel, Calcium-activated potassium channel
01
Overview
KCa1.1 (KCNMA1) is the alpha subunit of the calcium-activated BK (Big Potassium) channel, a large conductance potassium channel activated by membrane depolarization and increases in intracellular calcium. It plays a crucial role in regulating smooth muscle tone, neuronal excitability, neurotransmitter release, and auditory processing. Dysfunction of KCa1.1 is associated with neurological disorders such as paroxysmal nonkinesigenic dyskinesia, epilepsy, and Liang-Wang syndrome.
- Other names
- BK channel alpha subunitbig potassium channel alpha subunitmSLO1MaxiK channelSLOHSloSlowpoke homolog
02
Mechanism of action
Potassium channel modulation; affects membrane hyperpolarization and excitability.
03
Biological functions
Regulation of smooth muscle toneModulation of neuronal excitabilityControl of neurotransmitter releaseElectrical tuning in cochlear hair cellsPotassium ion transportRegulation of membrane potential
04
Disease associations
Paroxysmal Nonkinesigenic Dyskinesia type 3Idiopathic Generalized Epilepsy type 16Liang-Wang syndromeNeurological disordersSmooth muscle dysfunctionSensory processing disorders
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