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Target intelligence / Profile preview
Potassium calcium-activated channel subfamily M regulatory beta subunit 2 (KCNMB2)
- Target
- KCNMB2
- Molecular classification
- Ion channel auxiliary subunit, Ion channel modulator, Other
01
Overview
Potassium calcium-activated channel subfamily M regulatory beta subunit 2 (KCNMB2) is an auxiliary beta subunit that associates with the pore-forming alpha subunit (KCNMA1) of large conductance calcium-activated potassium (BK or MaxiK) channels, greatly modifying their gating kinetics and calcium sensitivity. KCNMB2 confers rapid and complete inactivation to the channel and is especially relevant in tissues such as smooth muscle and neurons, where it modulates physiological processes like muscle tone and excitability. Although KCNMB2 is fundamental to functional diversity of BK channels, it is not typically the direct molecular target of current pharmacological agents; rather, it modulates the properties of the core BK channel[1][2][5].
- Other names
- Potassium large conductance calcium-activated channel, subfamily M, beta member 2Calcium-activated potassium channel subunit beta-2MaxiK channel beta-subunit 2BK channel beta subunit 2Slo-beta-2Charybdotoxin receptor subunit beta-2Big potassium channel beta subunit 2K(VCA)Beta-2Hbeta2Large conductance calcium-activated potassium channel beta 2 subunitBKbeta2
02
Mechanism of action
Modulation of BK (large conductance calcium-activated potassium) channel gating/inactivation\nAlters sensitivity of alpha subunit (KCNMA1) to voltage and calcium
03
Biological functions
Modulation of potassium channel gatingRegulation of smooth muscle toneRegulation of neuronal excitabilityRegulation of channel inactivation
04
Disease associations
EpilepsyCurrarino syndromeOther (roles in neurophysiology and smooth muscle function; disease involvement is less established)
05
Safety considerations
Off-target modulation of smooth muscle and neuronal excitability (for potential drugs)Potential to alter blood pressure, muscle tone, or neuronal firing with systemic modulators
06
Interacting drugs
Charybdotoxin (as a tool/ligand rather than drug)
2 more in the full profile.
07
Biomarkers
No clinically established biomarkers for patient selection or monitoring
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