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Target intelligence / Profile preview
Potassium calcium-activated channel subfamily N member 1 (KCNN1)
- Target
- KCNN1
- Molecular classification
- Ion channel, Calcium-activated potassium channel, Potassium channel, Membrane protein
01
Overview
The **Potassium calcium-activated channel subfamily N member 1 (KCNN1)** encodes a small conductance calcium-activated potassium channel (KCa2.1 or SK1 channel) that is an integral membrane protein mediating voltage-independent potassium ion transport across the cell membrane. This channel is activated by increases in intracellular calcium, acting before membrane hyperpolarization, and is critically involved in regulating neuronal excitability by contributing to the slow component of the afterhyperpolarization (AHP) following action potentials. KCNN1 is implicated in several physiological processes and diseases, including neuronal signaling and cardiovascular conditions[1][3][5][7][10].
- Other names
- Small conductance calcium-activated potassium channel protein 1SK1 channelKCa2.1
02
Mechanism of action
Blockade of channel inhibits afterhyperpolarization, increasing neuronal excitability (as with apamin) Positive modulation enhances channel opening, decreasing excitability
03
Biological functions
Regulation of neuronal excitabilityMediation of afterhyperpolarization in neuronsControl of synaptic response durationModulation of membrane potential
04
Disease associations
Neurodegenerative diseaseCardiovascular diseaseChannelopathyOther
05
Safety considerations
Potential for altered neuronal excitability leading to seizures or arrhythmias if dysregulatedChannel inhibition may increase risk of neurotoxicity
06
Interacting drugs
Apamin
1 more in the full profile.
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