Drug pipeline
Full profile accessExplore the programs pursuing this target and their development progress.
- Drug candidates
- Developers
- Development stage
Target intelligence / Profile preview
Potassium Calcium-Activated Channel Subfamily T Member 1 (KCa4.1)
- Target
- KCa4.1
- Molecular classification
- Ion Channel, Potassium channel, Calcium/Sodium Activated Channel
01
Overview
KCa4.1, also known as KCNT1 or SLACK, is a sodium-activated potassium channel subunit that plays a crucial role in regulating neuronal excitability and ion conductance. It is primarily active in neurons within the brain, where it transports potassium ions out of cells to help maintain membrane potential and cellular homeostasis. Gain-of-function mutations in KCNT1 are associated with severe neurological disorders, including Ohtahara syndrome, malignant migrating partial seizures of infancy (MMPSI), and autosomal dominant nocturnal frontal lobe epilepsy, due to excessive neuronal firing and seizures.
- Other names
- KCNT1SLACKSlo2.2EIEE14ENFL5
02
Mechanism of action
Modulation of neuronal excitability via potassium ion conductance.
03
Biological functions
Regulation of neuronal excitabilityPotassium ion transportRegulation of membrane potentialNeurotransmitter release
04
Disease associations
Ohtahara syndromeMalignant migrating partial seizures of infancy (MMPSI)Autosomal dominant nocturnal frontal lobe epilepsy
05
Safety considerations
Potential for off-target effects due to broad expression in neurons.Challenges in developing highly selective modulators.
Beyond the preview
Go deeper on Potassium Calcium-Activated Channel Subfamily T Member 1 (KCa4.1).
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Clinical trials
Full profile accessFollow the clinical studies evaluating therapies directed at this target.
- Trial design
- Status
- Readouts
Competitive landscape
Full profile accessCompare approaches across drug candidates, modalities, and indications.
- Programs
- Modalities
- Indications
Literature & evidence
Full profile accessInvestigate the research and source evidence behind target biology and development.
- Publications
- Sources
- Analysis
Patents
Full profile accessExplore patent activity around therapies and technologies addressing this target.
- Patents
- Assignees
- Technologies
Research & analysis
Full profile accessConnect target biology, drug development, and emerging evidence in your research.
- Biology
- Development news
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on Potassium Calcium-Activated Channel Subfamily T Member 1 (KCa4.1).