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Potassium channel protein Kv1.5 subunit (Kv1.5)
- Target
- Kv1.5
- Molecular classification
- Ion channel, Potassium channel, Voltage-gated ion channel
01
Overview
Kv1.5 is a voltage-gated potassium channel subunit that forms homotetrameric or heterotetrameric channels in the cell membrane. It plays a crucial role in the repolarization of atrial action potentials and contributes to the ultrarapid delayed rectifier current (IKur) in the heart. Kv1.5 also regulates vascular tone in pulmonary arteries and influences insulin secretion in pancreatic beta cells. Mutations and dysregulation of Kv1.5 have been linked to atrial fibrillation, sudden cardiac death, and pulmonary hypertension.
- Other names
- KCNA5Potassium voltage-gated channel subfamily A member 5Shaker-related subfamily member 5IKur
02
Mechanism of action
Channel blockade (for blockers); Modulation of channel expression/activity via kinases (PKC, PKA)
03
Biological functions
Repolarization of cardiac action potentialRegulation of resting membrane potentialRegulation of vascular tonePotassium ion transport
04
Disease associations
Atrial fibrillationSudden cardiac death syndromesPulmonary hypertension
05
Safety considerations
Potential for pro-arrhythmic effects if channel blockade is excessive or non-selective.
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