Potassium channel regulatory protein (KCNRG)

Potassium channel regulatory protein (KCNRG) is a soluble, ER-associated protein found predominantly in lung tissue and other organs. It forms hetero-tetramers with voltage-gated potassium channels (Kv1 family), specifically interacting with the N-terminus (T1 domain) and inhibiting potassium channel activity by retaining these channels in the endomembrane system. KCNRG serves as a candidate tumor suppressor gene, as its activity is associated with reduced cell proliferation. Mutations or loss of KCNRG expression have been observed in various cancers, including hepatocellular carcinoma. KCNRG is also recognized as an autoantigen in autoimmune polyendocrine syndrome type 1 and may have roles in nonfatal respiratory diseases such as asthma and chronic bronchitis

Other names

KCNRGPotassium channel regulatorProtein CLLD4CLLD4DLTETPotassium channel regulatory proteinPutative potassium channel regulatory protein

KCNRG downregulates K+ channel activity by assembly interference or retention in endomembranes, leading to reduced cell proliferation by suppressing potassium channel activity and interfering with membrane potential dynamics. Loss or mutation of KCNRG function in disease may result in increased K+ channel activity and abnormal cell proliferation.